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Pilot & Production SIP Fermentation Systems



Scale With Confidence — SIP Fermenters for Every Stage

Flexible, High-Performance Stainless Steel Systems Ranging from 30 L to 1000 L. Fully customized to meet your process, your workflow, and your production goals.

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Overview

Winpact SIP systems are engineered for durability, precision, and seamless operation at pilot and production scale. Each vessel is constructed from high-grade 316L stainless steel and finished with orbital welding to ensure exceptional strength, cleanliness, and long-term reliability in demanding bioprocessing environments. A vibrant 10.4″ color touchscreen interface provides intuitive, real-time control of all critical parameters, making complex sterilization and cultivation workflows simple to manage. These design elements come together to deliver a robust, easy-to-operate platform ideal for scaling from development to full-scale production.

Features

  • Premium 316L Stainless Steel Construction
  • Built from the highest-grade materials for durability, cleanability, and long-term bioprocess reliability.
  • Precision Orbital Welding
  • Ensures ultra-smooth internal surfaces with minimal residue buildup—ideal for sanitary operation and easy cleaning.
  • Scalable Vessel Options (30 L to 1000 L)
  • A full range of working volumes to support seamless progression from pilot experiments to full-scale production.
  • 10.4″ Full-Color Touchscreen Interface
  • Intuitive, industrial-grade control panel for real-time monitoring and simplified operation.
  • Advanced 15-Step Programmable Control
  • Automate complex sterilization and cultivation routines with remote monitoring capabilities.
  • High-Efficiency Jacketed Design
  • Provides exceptional heating and cooling performance for precise temperature regulation.
  • Integrated Exhaust Pressure Relief Valve
  • Enhances operational safety by preventing over-pressurization and protecting both vessel and operator.
  • Comprehensive Safety Architecture
  • Multiple built-in safety systems ensure stable, worry-free operation during long or critical runs.
  • Extensive Optional Device Portfolio

  • Expand functionality with gas-mixing modules, mass-flow controllers, off-gas analyzers, additional pumps, and more.

  • Complete Customization for Your Process

  • Every SIP system can be configured to meet your exact application requirements—from sensors and gas-delivery paths to control modules, impeller designs, and vessel size.

  • On-Site Installation & Training

  • Professional installation and hands-on training ensure your system is correctly integrated, fully operational, and ready for production from day one.



Specifications

 

FS-100/200 SIP Fermentation System Specifications

System Specifications

Capacity 100L 200L
Total volume 120L 268L
Working volume 100L 200L
Dimension Approx. 170Wx130Dx245H cm, Open distance of headplate lift : 60 cm) Approx. 200Wx150Dx330H cm, Open distance of headplate lift : 40 cm
Vessel and jacket maximum working pressure 3 bar (43.5 psig) / 3 bar (43.5 psig)
Type Double layered fully enclosed capsule-type tank, with an outer temperature protective layer
Material Direct contact to medium - 316L stainless steel; all others - 304 stainless steel
Surface finish Interior polish ≦ 25 Ra/in (0.6 μm) Mechanical polishing; Electropolish optional
Exterior polish ≦ 32 Ra/in (0.8 μm) Mechanical polishing; Electropolish optional
Ports Ports designed according to user requirements
Piping and valve materials Parts that directly contact with the product/medium uses 316L stainless steel (≤25 Ra/in) internal polished tubing (BPE standard) :
  • A. Internal EP polished diaphragm type pneumatic valve and manual valve (BPE standard)
  • B. Tubing all welded with orbital welding
  • C. Vessel bottom drain uses a diaphragm valve, to minimize dead volume
  • D. Piping designed for ease of transfer to scale up
  • (can be used as a seed fermentation system)
    or downstream process
Parts that do not directly contact product/medium
A. Constructed with 304 stainless steel
Controller 12" color industrial touch screen
* User-friendly, graphical control interface
* Includes secure user accounts, with different levels of access
* Use stainless-steel controller cabinet (100 L and above only)
* Modularized and standardized design (Module Skid):
ergonomically designed according to height, ease of vessel clean up, and ease of extraction in relation to vessel bottom valve
* Includes maintenance page with system diagnostics
* All programmed setting values are automatically stored into the built-in memory; the settings will not be lost in case of power outage/interruption.
When power is restored, the interrupted process will automatically resumed
Setting * Automated sterilization process
* Automated fermentation program
DO * 0-200%, Control range: 0-100%, adjustable
* Software electrode calibration, with automatic temperature compensation function
* Includes one set of side-inserted stainless steel autoclavable DO electrode
* DO Stat features with intelligent feeding
pH * PID control with adjustable deadband
* Control range 0 to 14 (2-12 for maximum precision), resolution: 0.01 pH
* Calibration function with automatic temperature compensation function
* Includes one set of side-inserted, autoclavable pH probe with stainless steel housing
* pH Stat features with intelligent feeding
Pump * Built-in peristaltic pumps
* Each feeding pump can run adjustable 15-step program
* Each pump can be adjusted for speed, forward and backward direction, and manual or automatic mode
* Each of the four peristaltic pumps can be designated for different functions: acid pump, base pump, antifoam pump, or substrate feeding pump
* Optional fifth and six peristaltic pump available
Temperature * Vessel temperature is measured with a side-inserted PT-100 temperature probe and maintained using PID control.
* Control range: 0-130°C, ±0.1°C. Operational range up to 0-60°C.
Agitation * Manual or automatic control of agitation speed
* 15-step program to change speed, or use DO cascade control
Air supply and exhaust Gas supply and dehumidifer: uses in-house air compressor or air dehumidifier
* Includes re-useable, autoclavable 0.2μm air filter for gas inlet
* Gas Inlet (air) Includes mass flow controller: 2 vvm maximum according to the vessel capacity
* Gas Inlet (oxygen) Includes pure oxygen rotameter (manual flow control): 1 vvm maximum according to the vessel capacity
* Includes oxygen gas solenoid valve, with automatic pulsed time control
Air outlet / Exhaust
* Exhaust port with stainless steel condenser
* Includes re-useable, autoclavable 0.2μm air filter
* Includes automated adjustable gas outlet valve to adjust vessel back pressure
* Can control manually or automatically via software

Utility Requirement

Capacity 100L 200L
Power Three phase 220V or 380V (note: can be customized to local standard)
Air At least 7 bar
200 L/min
flow rate		 400 L/min
flow rate
Dehumidified
Oil-free
Peripheral factory water supply Cooling water (tap water, at least 15oC below working temperature, must be soft water);
Pressure at least 2 bar
Process water RO Water
Plant steam ≥ 2 bar; dry steam with no entrained condensate
Process steam ≥ 2 bar; dry steam with no entrained condensate
Drain In situ drain; ≥ 2"

* Customization on the SIP Fermentation system available upon request.

* Please contact your regional manager for evaluation request.

* For bigger capability systems, please contact Major Science and/or our distributor partners.

Optional Accessories Items

Gas Mixing Station

The gas mixing station allows the user to optimize cell growth conditions by independently supplying up to four gasses to the fermentation process. Parameters such as dissolved oxygen and pH can be controlled by adjusting the gas composition supplied to the system. Four manually adjusted flowmeters control the flow rate of each gas, while the 4 solenoid valves automatically open or close in response to the culture conditions. The Gas Mixing Station can be operated in either manual or automatic modes.

Oxygen Mass Flow Controller

Maintain optimal control over culture DO level by installing this optional mass flow controller. The mass flow controller can accurately adjust the flow rate of incoming oxygen and is resistant to fluctuations in gas pressure, ensuring precise control and repeatibility of experimental conditions

  • A. Cascade control scheme
  • B. Integrated into controller for simple and automated operation

CO2 / O2 Off-Gas Analyzer

The CO2 / O2 off-gas analyzer provides real-time measurement of carbon dioxide and oxygen concentration of the bioreactor exhaust gas. The CO2 concentration is determined using a self-calibrating non-dispersion infrared sensor, while an electrochemical sensor monitors the oxygen concentration. Using this information, the user can continuously monitor metabolism and analyze cell growth parameters.

ORP Probe

The ORP probe measures the oxidation-reduction potential of the fermentation media, which is a crucial indicator of anaerobic conditions/reactions. This low-maintenance and sterilizable probe is designed to withstand repeated experiments.

Electropolish (EP) of Vessel Tank

Electropolish of the vessel tank is offered as a higher sanitary grade surface finish. EP surface finish is an addition to the standard mechanical polish (MP) which provides a smoother surface area to minimize residual residue.

* Note that this option MUST be requested at your initial inquiry, later-on additions after completion of construction is not possible

Transfer Piping

Transfer piping of your resulting product/medium between vessels is offered for the convenience of operation.

Automated transfer using pressure in addition to directional control with valve regulations offers fast and easy operation.



Media

 



Downloads

 Winpact Catalogue


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Every SIP installation is unique, and our technical specialists are ready to design a system that fits your process precisely. Share your application details, and we’ll develop a fully customized quote built around your volume, instrumentation, and control needs.

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